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ucht1  (Bio X Cell)


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    Bio X Cell ucht1
    Ucht1, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 94/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+cd3+antibody+ucht1/InVivoMAb+anti-human+CD3/us12473377-216-65-67
    Average 94 stars, based on 29 article reviews
    ucht1 - by Bioz Stars, 2026-11
    94/100 stars

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    Related Articles

    Injection:

    Article Title: KT-253, A Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy Than MDM2 Small Molecule Inhibitors
    Article Snippet: Murine double minute 2 (MDM2) is an E3 ligase that inhibits the tumor suppressor protein p53.. Clinical trials employing small-molecule MDM2/p53 interaction inhibitors have demonstrated limited activity, underscoring an unmet need for a better approach to target MDM2.. KT-253 is a highly potent and selective heterobifunctional degrader that overcomes the MDM2 feedback loop seen with small-molecule MDM2/ p53 interaction inhibitors and induces apoptosis in a range of hematologic and solid tumor lines.

    Article Title: KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors
    Article Snippet: .. CD3 + T cells were depleted by adding anti-CD3 antibody UCHT1 (Bio X Cell, 1 μL per million cells) and incubating for 30 minutes, on ice, prior to intravenous injection. .. CD3 + T cells were depleted by adding anti-CD3 antibody UCHT1 (Bio X Cell, 1 μL per million cells) and incubating for 30 minutes, on ice, prior to intravenous injection.



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    Image Search Results


    ( a ) CytoF immunophenotyping of patients total CD3 + T cells, NK cells and indicated NK cell subsets. Controls 0–3 y.o. (n = 2), Controls 4–15 y.o. (n = 9), Controls 16–100 y.o. (n = 28), pediatric patients (LOH) (n = 5), adult patients (LOH) (n = 2), heterozygous individuals (n = 3), mean ± s.d. Statistical significance was assessed with multiple Mann Whitney tests adjusted for multiple testing. *p<0.05. ( b ) Assessment of T cell proliferation of patients P1, P2 and P3. (top) gating strategy, (bottom) CFSE dilution plots. ( c ) Intracellular TNF production of CD4 + and CD8 + T cell blasts in homozygous (n = 4), heterozygous (n = 2) and wildtype (n = 5) state of CBL Ub LOF variants. Line indicates the mean of the displayed datapoints. ( d,e ) Intracellular and extracellular cytokine production by patients T fh cells stimulated with CD2/CD3/CD28 under T h 0 conditions for 5 days. ( d ) Intracellular staining of the indicated cytokines. Healthy donors (n = 17), CBL-LOH patients (n = 4). Mann-Whitney testing with correction for multiple testing did not reveal significant (p< 0.05) differences between healthy donors and CBL-LOH patients. Line indicates the mean of the displayed datapoints. ( e ) Extracellular detection of cytokines by ELISA. Healthy donors (n = 6), CBL-LOH patients (n = 3). Mann-Whitney testing with correction for multiple testing did not reveal significant (p< 0.05) differences between healthy donors and CBL-LOH patients. Line indicates the mean of the displayed datapoints.

    Journal: Nature Immunology

    Article Title: Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function

    doi: 10.1038/s41590-025-02381-7

    Figure Lengend Snippet: ( a ) CytoF immunophenotyping of patients total CD3 + T cells, NK cells and indicated NK cell subsets. Controls 0–3 y.o. (n = 2), Controls 4–15 y.o. (n = 9), Controls 16–100 y.o. (n = 28), pediatric patients (LOH) (n = 5), adult patients (LOH) (n = 2), heterozygous individuals (n = 3), mean ± s.d. Statistical significance was assessed with multiple Mann Whitney tests adjusted for multiple testing. *p<0.05. ( b ) Assessment of T cell proliferation of patients P1, P2 and P3. (top) gating strategy, (bottom) CFSE dilution plots. ( c ) Intracellular TNF production of CD4 + and CD8 + T cell blasts in homozygous (n = 4), heterozygous (n = 2) and wildtype (n = 5) state of CBL Ub LOF variants. Line indicates the mean of the displayed datapoints. ( d,e ) Intracellular and extracellular cytokine production by patients T fh cells stimulated with CD2/CD3/CD28 under T h 0 conditions for 5 days. ( d ) Intracellular staining of the indicated cytokines. Healthy donors (n = 17), CBL-LOH patients (n = 4). Mann-Whitney testing with correction for multiple testing did not reveal significant (p< 0.05) differences between healthy donors and CBL-LOH patients. Line indicates the mean of the displayed datapoints. ( e ) Extracellular detection of cytokines by ELISA. Healthy donors (n = 6), CBL-LOH patients (n = 3). Mann-Whitney testing with correction for multiple testing did not reveal significant (p< 0.05) differences between healthy donors and CBL-LOH patients. Line indicates the mean of the displayed datapoints.

    Article Snippet: 154Sm , CD3 , UCHT1 , 3154003B , Fluidigm.

    Techniques: MANN-WHITNEY, Staining, Enzyme-linked Immunosorbent Assay